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https://dspace.ctu.edu.vn/jspui/handle/123456789/38088| Title: | Synthensis and cytotoxicity of polyhydroxylated cholesterol derivatives |
| Authors: | Dinh, Thi Ha Doan, Lan Phuong Pham, Quoc Long Ngo, Dai Quang Tran, Thi Thu Thuy |
| Keywords: | Cholesterol Cytotoxicity Polyhydroxylated derivative |
| Issue Date: | 2018 |
| Series/Report no.: | Vietnam Journal of Science and Technology;Vol.56(No.04) .- P.467–473 |
| Abstract: | Eight polyhydroxylated cholesterol derivatives (l-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibit human hepatocellular carcinoma cell line (Hep-G2) with IC50 values of 11.59, 11.89 and 6.87 µM' respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50: 2.28 µM. |
| URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/38088 |
| ISSN: | 2525-2518 |
| Appears in Collections: | Vietnam journal of science and technology |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 4.4 MB | Adobe PDF | ||
| Your IP: 3.146.221.204 |
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