Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/5244
Title: Au@SiO₂ core/shell nanoparticle assemblage used for highly sensitive SERS-based determination of glucose and uric acid
Authors: Trần, Thị Bích Quyên
Hwang, Bing-Joe
Rick, John
Chen, Kuan-Jung
Chang, Chun-Chao
Pan, Chun-Jern
Su, Wei-Nien
Keywords: SERS
Au@SiO₂ core/shell nanoparticles(Au@SiO₂ NPs)
Rhodamine 6G (R6G)
Glucose
Uricacid
Issue Date: 2013
Series/Report no.: Journal of Raman Spectroscopy;12 .- p.1671–1677
Abstract: The use of Au@SiO₂ core/shell nanoparticle (NP) assemblage with highly sensitive surface-enhanced Raman scattering (SERS) was investigated for the determination of glucose and uric acid in this study. Rhodamine 6G dye molecules were used to evaluate the SERS enhancement factor for the synthesized Au@SiO₂ core/shell NPs with various silica shell thicknesses. The enhancement of SERS signal from Rhodamine 6G was found to increase with a decrease in the shell thickness. The core/shell assemblage with silica layer of 1–2 nm over a Au NP of ~36 nm showed the highest SERS signal. Our results show that the SERS technique is able to detect glucose and uric acid within wide concentration ranges, i.e. 20 ng/dL to 20 mg/dL (10⁻¹² –10⁻³ M) and 16.8 ng/dL to 2.9 mg/dL (10⁻¹¹ –1.72 × 10⁻⁴ M), respectively, with associated lower detection limits of ~20 ng/dL (~1.0 × 10⁻¹² M) and ~16.8 ng/dL (~1.0 × 10⁻¹¹ M). Our work offers a low-cost route to the fabrication of agile sensing devices applicable to the monitoring of disease progression.
URI: http://localhost:8080//jspui/handle/123456789/5244
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