https://dspace.ctu.edu.vn/jspui/handle/123456789/13215 Vietnam Academy of Science and Technology Thu, 23 Apr 2026 03:36:58 GMT 2026-04-23T03:36:58Z https://dspace.ctu.edu.vn/jspui/handle/123456789/119593 Title: Pancreatic lipase inhibitory and antiacne activity of Piper betle: Kinetic studies, in silico docking, and chemical characterization of bioactive compounds Authors: Shinde, Rani A.; Patil, Mohini R.; Patil, Ravindra H.; Vishwakarma, Kishor S.; Maheshwari, Vijay L. Abstract: Lipases play important roles in obesity and skin infections. Piper betle (Piperaceae) is widely cultivated and used in daily life, and it is a rich source of lead compounds for treating skin infections. This study reveals the anti-acne and pancreatic lipase inhibitory potential of Piper betle leaf extract using in vitro and in silico molecular docking. The inhibitory potential of 13 selected plant extracts was evaluated at various concentrations (5-25 µg/mL). The ethyl acetate extract of Piper betle, which showed strong pancreatic lipase inhibitory activity, was further fractionated by preparative thin-layer chromatography. Eluted bands demonstrating strong inhibitory activity were characterized by high-performance liquid chromatography and gas chromatography. The purified compounds, namely anodendroside E, 2-monoacetate, and SH-cyclopropa[3,4]benz(1,2-e)azulen-5-one, were identified and showed over 90% pancreatic lipase inhibition. The isolated compounds also exhibited strong dose-dependent inhibitory effects on Propionibacterium acnes. These observations were consistent with molecular docking studies, which showed that anodendroside E, 2-monoacetate binds to the allosteric site with a binding energy of -7.0 kcal/mol. This binding site is stabilized by hydrogen and carbon-hydrogen bonds contributed by Phe 354, Asp 130, and Ser 103. These findings suggest that the pancreatic lipase inhibitory and anti-acne effects of Piper betle are attributed to anodendroside E, 2-monoacetate. Mon, 01 Jan 2024 00:00:00 GMT https://dspace.ctu.edu.vn/jspui/handle/123456789/119593 2024-01-01T00:00:00Z https://dspace.ctu.edu.vn/jspui/handle/123456789/119590 Title: A new cytotoxic saponin from the ethyl acetate extract of myrsine semiserrata wall Authors: Nguyen, Thi Binh Yen; Nguyen, Thuy Linh; Vu, Van Nam; Trieu, Quy Hung; Doan, Thi Mai Huong; Pham, Van Cuong Abstract: Myrsine semiserrata Wall. (Primulaceae) is an evergreen shrub found in some Asian regions including Northern Vietnam, Southern China, India, Nepal, and Myanmar. Its bark and leaves are utilized in leather tanning, while the fruit serves as a commonly used antiseptic agent. A phytochemical study on the ethyl acetate extract from the aerial parts of this plant led to the isolation of a new saponin, 3-O-α-L-arabinopyranosyl juglangenin A (1), and four known triterpenes: lupeol acetate (2), taraxerone (3), cucurbitacin D (4), and cucurbitacin H (5). Their structures were elucidated by analyzing 1D and 2D NMR, and HR-ESI-MS spectroscopic techniques. All isolated compounds were tested for their cytotoxicity on human cancer cell lines: HepG2, KB, MCF7, and A549. Compounds 4 and 5 exhibited potent activity against HepG2 and KB cell lines with IC₅₀ values ranging from 1.06 to 5.99 μM. Saponin 1 demonstrated action against all tested cancer cell lines with IC₅₀ values of 74.26, 42.83, 40.65, and 70.82 µM, respectively. Mon, 01 Jan 2024 00:00:00 GMT https://dspace.ctu.edu.vn/jspui/handle/123456789/119590 2024-01-01T00:00:00Z https://dspace.ctu.edu.vn/jspui/handle/123456789/112366 Title: Transforming environmental sustainability: Lime treated used coffee grounds for innovative eco-friendly epoxy composite materials Authors: Nguyen, Tuan Anh; Doan, Thi Yen Oanh; Ngo, Thuy Van; Nguyen, Thi Huong; Nguyen, Thi Thu Phuong; Bui, Thi Thu Trang; Nguyen, Quang Tung; Dam, Xuan Thang; Nguyen, Kim An; Nguyen, Minh Viet Abstract: This study proposes an innovative method to recycle used coffee grounds into environmentally friendly epoxy composite materials while emphasizing the sustainability of this process. This approach focuses on using lime treated coffee grounds as a reinforcing agent for epoxy composites. Diverse analytical techniques such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), ther mogravimetric analysis (TGA) and mechanical testing according to international standards have been used to evaluate the properties of materials. Coffee grounds have been treated by soaking in Ca(OH)₂, solution with different concentrations (0.1 м, 0.3 M) and processing times (1, 3 and 5 days), then combined with epoxy resin to form composite materials. The results showed that using coffee grounds treated with Ca(OH)₂, significantly improved the stability and performance of epoxy composites. The best fire retardant performance was achieved with a Ca(OH)₂ solution with a concentration of 0.3. M. and a treatment time of 3 days, with a limiting oxidation index (LOI) of 21.6%. Furthermore, the compressive strength increased by about 20.79% compared to pure epoxy resin. This study highlights the potential of optimizing coffee grounds treatment parameters with Ca(OH)₂ to improve the properties and performance of epoxy composites, thereby promoting practical application and environmental protection. Mon, 01 Jan 2024 00:00:00 GMT https://dspace.ctu.edu.vn/jspui/handle/123456789/112366 2024-01-01T00:00:00Z https://dspace.ctu.edu.vn/jspui/handle/123456789/112363 Title: Crystal structure and photophysical properties of (K²-(N,O)-5,7-dichloro-2-methyl-8-quinolinolate) di (pentafluorophenyl)-borane: Experiment and density functional theory calculations Authors: Nguyen, Minh Phuong; Nguyen, Thac Huy; Nguyen, Thuy Huong Nhi; Le, Thi Hong Hai; Tran, Ngoc Dung; Pham, Van Thong; Nguyen, Thi Xuyen; Hoang, Van Hung; Nguyen, Thi Mo; Nguyen, Thi Minh Hue Abstract: Over the past decade, the boron Schiff bases (BOSCHIBAs) have garnered significant attention due to their facile and eco friendly synthesis, nonlinear and linear optical properties, and sensitivity in solar cells. Recently, luminescent boron(III) complexes have been successfully employed as emitters in organic lightemitting diodes (OLEDs). The [B(C₆F₅)₂(MeCIQ)] complex was synthesized by reacting 5,7-dichloro 2-methylquinoline-8-ol with tripentafluorophenylborane, and its structure was determined via single crystal X-ray diffraction (SC-XRD). The photophysical properties of the compound in various solvents were investigated using UV-Vis and fluorescence spectra in combination with DFT calculations. Analysis based on HOMO-LUMO energy, emission and absorption spectra, and other parameters indicates that [B(C₆F₅)₂ (MeCIQ)] exhibits great potential as a blue light emitter in OLEDs. Mon, 01 Jan 2024 00:00:00 GMT https://dspace.ctu.edu.vn/jspui/handle/123456789/112363 2024-01-01T00:00:00Z