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Title: | Cytotoxic and antimicrobial benzodiazepine and phenolic metabolites from Aspergillus ostianus IMBC-NMTP03 |
Authors: | Tran, Hong Quang Le, Ngoc Anh Tran, Thi Hong Hanh Nguyen, Xuan Cuong Nguyen, Thi Thanh Ngan Nguyen, Quang Trung Nguyen, Hoai Nam |
Keywords: | Aspergillus ostianus Benzodiazepine Phenolic Cytotoxic Antimicrobial |
Issue Date: | 2021 |
Series/Report no.: | Vietnam journal of Chemistry;Vol.59, No.05 .- P.660-666 |
Abstract: | Six benzodiazepine alkaloids and two phenolics were isolated from an ethyl acetate extract of the fungal strain Aspergillus ostianus IMBC-NMTP03 fermentation culture. Their chemical structures were elucidated as circumdatins D (1), E (2), J (3), and 1 (4), cycloanthranilylproline (5), and (11a5)-2,3-dihydro-7-methoxy-1H-pyrrolo[2,1- c][1,4]benzodiazepine-5,11(10H,11a/f)-dione (6), 4-hydroxybenzoic acid (7), and syringaldehyde (8) by spectroscopic methods, including ID and 2D NMR and mass spectra in comparison with the literature data. Compounds 2, 4, and 5 showed cytotoxicity toward KB, MCF-7, and LNCaP cancer cell lines (41.14-49.76% cell death) while 7 was cytotoxic against HL-60, KB and LNCaP cells (41.77-47.06% cell death). Compounds 1-3 and 5-8 displayed antimicrobial activity against Emerococcus faecalis and Candida albicans, with MIC values ranging from 18.7-100 µM. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/103824 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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