Phytochemical study of Euphorbia cyathophora collected in Dan Phuong, Hanoi and its antidengue activity against DENV1-4 virus serotypes

Abstract

The ethanol extract from the leaves and twigs of Euphorbia cyathophora showed antiviral activity against four dengue virus serotypes (DENV1-4), with PRNT₅₀ values of 15.625-62.5 µg/mL. Eight compounds including germanicol acetate (1), cymbopogone (2), 1-heptacosanol (3), ethyl α-L-arabinofuranoside (4), quercetin (5), 3-acetoxy-5,7,3',4'- tetrahydroxyflavone (6), 3-acetoxy-5,7,4-trihydroxyflavone (7), 4'-acetoxy-3,5,7-trihydroxyflavone (8) were isolated from this extract. Compounds 2-8 were isolated for the first time from Euphorbia cyathophora. Antiviral activity evaluation of compounds 1-3, 5-7 on DENV1-4 serotypes revealed that 7 was the most active compound with PRNT₅₀ values of 23.8-95.2 μΜ.