Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/103989
Title: Phytochemical study of Euphorbia cyathophora collected in Dan Phuong, Hanoi and its antidengue activity against DENV1-4 virus serotypes
Authors: Nguyen, Thi Dung
Pham, Thi Ninh
Nguyen, Thi Luu
Nguyen, The Anh
Vu, Thi Bich Hau
Nguyen, Thi Thu Thuy
Ho, Ngọc Anh
Phan, Dieu Hang
Tran, Thi Phuong Thao
Keywords: Euphorbia cyathophora
Antidengue activity
Secondary metabolites
Issue Date: 2023
Series/Report no.: Vietnam journal of Chemistry;Vol.61, No.03 .- P.371-377
Abstract: The ethanol extract from the leaves and twigs of Euphorbia cyathophora showed antiviral activity against four dengue virus serotypes (DENV1-4), with PRNT₅₀ values of 15.625-62.5 µg/mL. Eight compounds including germanicol acetate (1), cymbopogone (2), 1-heptacosanol (3), ethyl α-L-arabinofuranoside (4), quercetin (5), 3-acetoxy-5,7,3',4'- tetrahydroxyflavone (6), 3-acetoxy-5,7,4-trihydroxyflavone (7), 4'-acetoxy-3,5,7-trihydroxyflavone (8) were isolated from this extract. Compounds 2-8 were isolated for the first time from Euphorbia cyathophora. Antiviral activity evaluation of compounds 1-3, 5-7 on DENV1-4 serotypes revealed that 7 was the most active compound with PRNT₅₀ values of 23.8-95.2 μΜ.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/103989
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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