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DC Field | Value | Language |
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dc.contributor.author | Nguyen, Thi Ha Trang | - |
dc.contributor.author | Tran, Thu Trang | - |
dc.contributor.author | Nguyen, Trung Nam | - |
dc.date.accessioned | 2024-06-27T12:32:46Z | - |
dc.date.available | 2024-06-27T12:32:46Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 1811-4989 | - |
dc.identifier.uri | https://dspace.ctu.edu.vn/jspui/handle/123456789/104018 | - |
dc.description.abstract | Poly (I:C) (Polyinosinic:polycytidylic acid) is a synthetic analog of double-stranded RNA binding toll-like receptor 3 (TLR3) and mimicking a virus infection in macrophage. Here, for the first time, we showed the inhibitory effects of eurycomanone on the production of IL-6, TNF-alpha and IL-10 of RAW 264.7 cells stimulated with poly (I:C). Eurycomanone inhibited production of pro-inflammatory cytokines including IL-6 and TNF-alpha of RAW 264.7 cells stimulated with poly (I:C) with the IC50 value being 5.14 +/- 0.60 uM and 2.32 +/- 0.40 uM, respectively. Interestingly, this compound also inhibited the production of anti-inflammatory cytokine IL-10 of RAW 264.7 cells stimulated with poly (I:C) with the IC50 value being 14.60 +/- 0.32 uM. These results suggested that eurycomanone has a potentially regulatory role on production of both pro-inflammatory and anti-inflammatory cytokines in macrophage in the mimicking context of virus infection. Whether eurycomanone inhibits the binding of poly (I:C)-TLR3 or intracellular signaling pathways needs further investigation. | vi_VN |
dc.language.iso | en | vi_VN |
dc.relation.ispartofseries | Vietnam journal of Biotechnology;Vol.21, No.03 .- P.435-441 | - |
dc.subject | Eurycomanone | vi_VN |
dc.subject | Poly (I:C) | vi_VN |
dc.subject | RAW 264.7 cells | vi_VN |
dc.subject | Inflammatory cytokines | vi_VN |
dc.title | Cytokine inhibitory activity of eurycomanone in RAW 264.7 cells stimulated with viral-mimicking poly (I:C) | vi_VN |
dc.type | Article | vi_VN |
Appears in Collections: | Công nghệ sinh học |
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