Evaluation of anti-inflammatory and bronchodilator effects of Dinh Suyen P/H extract on experimental animals

Abstract

The purpose of this study was to evaluate the anti-inflammatory and the bronchodilator effects of Dinh Suyen P/H extract in experimental animals. The anti-inflammatory activity of Dinh Suyen P/H extract was evaluated in an induced peritoneal inflammation model in rats and amiant-induced granuloma model in mice. To evaluate the bronchodilator effect, the bronchospasmolytic activity in anesthetized guinea pig model was used. The present study demonstrated that Dinh Suyen P/H extract at dose 6.22 g/kg per day and 18.66 g/kg per day inhibited acute inflammatory activity in rats. The results obtained in the amiant-induced granuloma in mice did not show evidence of chronic anti-infammatory effect of Dinh Suyen P/H extract at dose 12.44 g/kg per day or 37.32 g/kg per day. In addition, the findings of this study indicated that Dinh Suyen P/H extract at dose 8.29g/kg per day inhibited the bronchocontriction in bronchospasmolytic activity in a guinea pig model.