Vui lòng dùng định danh này để trích dẫn hoặc liên kết đến tài liệu này: https://dspace.ctu.edu.vn/jspui/handle/123456789/107760
Nhan đề: Resistome and plasmidome in an extensively drug-resistant extra-intestinal pathogenic Escherichia coli isolated from a one-year-old child with respiratory distress syndrome
Tác giả: Nguyen, Van Anh
Nguyen, Thuy Duong
Tran, Thi Thanh Tam
Nguyen, Quang Huy
Từ khoá: Extra-intestinal pathogenic Escherichia coli (ExPEC)
Resistome
Plasmidome
Extensively drug resistance
Carbapenem resistance
Whole genome sequencing
Năm xuất bản: 2023
Tùng thư/Số báo cáo: Vietnam journal of Biotechnology (Tạp chí Công nghệ sinh học);Vol.21, No.02 .- P.305-316
Tóm tắt: The global health is facing a growing menace of multidrug-resistant and extensively drug-resistant bacteria over time. Genomic plasticity of pathogenic Escherichia coli allows them to continuously develop and acquire genetic elements associated with antibiotic resistance, including resistance to last resort drugs like carbapenems – only used for the treatment of multidrug-resistant bacterial infections. This study aimed at identifying resistome and plasmidomes carrying antibiotic-resistant genes (ARGs) in an extensively drug-resistant extra-intestinal pathogenic E. coli strain XP817 isolated from a one-year-old child with respiratory distress syndrome. Whole genome analysis of strain XP817 revealed 68 ARGs documented in the Comprehensive Antibiotic Resistance Database (CARD). Notably, strain XP817 possessed 12 ARGs and mutations responsible for its extensively drug-resistant phenotype to aminoglycosides (aacC2 and rmtB), tetracycline (tetA and tetR), bleomycin (bleMBL), chloramphenicol (mdtM), penicillin and cephalosporin (blaCTX-M-27 and blaAmpC), fluoroquinolones (gyrA and parC), macrolide (mphA) and carbapenem (blaNDM-1). Furthermore, five plasmids carrying seven ARGs originated from E. coli strain ECCHD184 (carrying mph(A)) and other species of Enterobacteriaceae family including Enterobacter hormaechei (carrying blaNDM-1 and bleMBL), Proteus mirabilis (carrying tet(A) and tetR), Raoultella ornithinolytica (carrying blaCTX-M-27) and Klebsiella pneumonia (carrying aacC2) were detected. In conclusion, our study underlines the crucial role of the ARG dissemination via horizontal gene transfer in E. coli as well as in the Enterobacteriaceae family.
Định danh: https://dspace.ctu.edu.vn/jspui/handle/123456789/107760
ISSN: 2815-5955
Bộ sưu tập: Công nghệ sinh học

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