Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/107798
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dc.contributor.authorTo, Minh Nhat-
dc.contributor.authorTran, Thu Trang-
dc.contributor.authorNguyen, Trung Nam-
dc.date.accessioned2024-10-23T03:19:25Z-
dc.date.available2024-10-23T03:19:25Z-
dc.date.issued2023-
dc.identifier.issn2815-5955-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/107798-
dc.description.abstractResveratrol is a naturally occurring compound with anti-inflammatory properties. However, the protective molecular mechanisms of resveratrol against LPS-induced inflammation have not been thoroughly known. In the present study, we examined the anti-inflammatory effect of resveratrol in inflammatory model using murine macrophage-like cell RAW264.7 stimulated with LPS. Resveratrol suppressed the production of inflammatory cytokines in LPS-stimulated RAW264.7 cells with the IC50 value as 17.5 ± 0.7 μM for IL-6, 14.2 ± 1.9 μM for IL-10, and 18.9 ± 0.6 μM for TNF-α. Gene expression of TLR4, MyD88 and NF-κB were significantly suppressed by resveratrol treatment in LPS-stimulated RAW264.7 cells. In conclusion, the anti-inflammatory property of resveratrol is potentially related to its inhibitory effecton TLR4/MyD88/NF-κB signaling pathway in macrophages.vi_VN
dc.language.isoenvi_VN
dc.relation.ispartofseriesVietnam journal of Biotechnology (Tạp chí Công nghệ sinh học Việt Nam);Vol.21, No.04 .- P.611-619-
dc.subjectMacrophagesvi_VN
dc.subjectInflammatory cytokinesvi_VN
dc.subjectLipopolysaccharidevi_VN
dc.subjectResveratrolvi_VN
dc.titleResveratrol inhibits cytokine production in LPS-stimulated RAW264.7 cells potentially through TLR4/MyD88/NF-κB pathwayvi_VN
dc.typeArticlevi_VN
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