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Title: | Chemical constituents of Syzygium cerasiforme leaves and their nitric oxide inhibitory activity in LPS-activated RAW264.7 cells |
Authors: | Bui, Hai Ninh Duong, Thi Dung Nguyen, Van Tuyen Bui, Huu Tai Phan, Van Kiem |
Keywords: | Myrtaceae Nitric oxide inhibitor Syzygium cerasiforme |
Issue Date: | 2024 |
Series/Report no.: | Vietnam journal of Chemitry;Vo.62, No.01 .- P.55-60 |
Abstract: | A phytochemical study of the methanolic extract of Syzygium cerasiforme leaves led to the isolation of seven compounds (1-7). Their chemical structures were identified as benzyl-6'-O-galloyl-β-D-glucopyranoside (1), 3-methoxy-4- hydroxyphenol 1-0-β-D-(6'-O-galloyl)-glucopyranoside (2), betulonic acid (3), 3-epi-betulinic acid (4), 7α-methoxy-stigmast-5-en-3β-ol (5), dihydrodehydrodi- coniferyl alcohol (6), and secoisolariciresinol (7), by HR-ESI-MS, 1D-and 2D NMR spectra, and by comparison with the previously published data. Compounds 1-7 exhibited NO production inhibitory activity in LPS-activated RAW264.7 cells with IC₅₀ values of 33.17, 25.51, 51.09, 54.17, 39.54, 6.98, and 58.12 µm, respectively, compared to that of the positive control compound, L-NMMA, which showed an IC₅₀ of 32.5 µm. This is the first report on these compounds from S. cerasiforme. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/109031 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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