Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/109037
Title: CLPC1 protein inhibition, antimycobacterial, and anti inflammatory properties of the metabolite from Streptomyces wuyuanensis collected in Nghe An province, Vietnam
Authors: Huynh, Thi Ngoc Ni
Pham, Thi Ninh
Nguyen, Thi Dung
Nguyen, Quynh Uyen
Ho, Ngoc Anh
Suh, Joo-Won
Tran, Van Chien
Cheng, Jinhua
Nguyen, Kim Nu Thao
Nguyen, Minh Duc
Tran, Thi Phuong Thao
Keywords: Antimycobacterial activity
ClpC1-protein
Indole-3-carboxylic acid
Mycobacterium tuberculosis
Streptomyces wuyuanensis
Issue Date: 2024
Series/Report no.: Vietnam journal of Chemitry;Vo.62, No.01 .- P.85-91
Abstract: Streptomyces wuyuanensis A79 was isolated from the soil samples collected in Quynh Luong mangrove forest, Quynh Luu district, Nghe An province, Vietnam. This strain demonstrated antimycobacterial activity against Mycobacterium smegmatis. Compound 1 (indole-3-carboxylic acid) was isolated from the culture extract of S. wuyuanensis (A79). This compound displayed the affection of ATPase activity of the recombinant ClpC1 protein, a regulatory protein of Mycobacterium tuberculosis. In addition, compound 1 exhibited anti-inflammatory activity through the inhibition of TNF-α on LPS-stimulated macrophage RAW264.7. This is the first time compound 1 (indole-3-carboxylic acid) has been isolated from S. wuyuanensis. Indole-3-carboxylic acid was also reported for the first time its inhibition of M. tuberculosis ClpC1 protein.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/109037
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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