Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/109039
Title: Flavonoids from Alpinia vietnamica, and their cytotoxic, antioxidative, and α-glucosidase inhibitory activities
Authors: Nguyen, Thanh Tra
Nguyen, Thi Thuy Hoa
Ba, Thi Cham
Le, Thi Tu Anh
Nguyen, Thi Thuy Linh
Ninh, The Son
Keywords: Alpinia vietnamica
Antioxidant
Cytotoxicity
Flavonoids
Rhizome
α-glucosidase inhibitory
Issue Date: 2024
Series/Report no.: Vietnam journal of Chemitry;Vo.62, No.01 .- P.98-102
Abstract: Phytochemical research of the 80% EtOH whole plant extract of Alpinia vietnamica H.Ð. Tran, Luu & Skornick resulted in the isolation and structural elucidation of seven compounds 1–7, including two flavones quercetin-3-O-α-l-rhamnosyl (1→2)-α-l-rhamnoside (1) and diosmetin (2), three flavanones pinocembrin (3), alpinetin (4) and 5-O-methylnaringenin (5), and two chalcones cardamonin (6) and helichrysetin (7). The isolated compounds have shown biological effects at different levels. Two chalcones 6–7 showed cytotoxicity toward four cancer cell lines KB, MCF7, A549, and HepG2, especially compound 7 strongly inhibited the growth of A549 cancerous cells with the IC50 of 6.81 µm. Flavone 1 strongly exhibited antioxidative activity to scavenge DPPH radicals with the IC50 of 51.68 µm. Flavone 2 and flavanone 4 moderately inhibited enzyme α-glucosidase with the IC50 values of 296.34–324.64 µm.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/109039
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

Files in This Item:
File Description SizeFormat 
_file_
  Restricted Access
1.45 MBAdobe PDF
Your IP: 3.145.12.233


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.