Design, synthesis, and biological evaluation studies of novel thiophene substituted thiazolidinones scaffold as promising antimicrobial agents

Abstract

Global public health is profoundly imperiled by antimicrobial resistance (AMR) and has made it extremely difficult to effectively control infectious diseases which are connected to it, so a new series of 5-benzylidene-2-(thiophen-2-yl)-3-(4H-1,2,4- triazol-4-yl)thiazolidin-4-ones (5a-o) is synthesized. Spectral techniques have been utilized to characterize and confirm the structures of targeted molecules. The outcomes are to be compared with typical drugs given that compounds are examined against grampositive and gramnegative strains of bacteria and fun gus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum.