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Title: | Compounds from aerial parts of Isodon lophanthoides and their effects of cytotoxicity and LPS-induced IL-1β and IL-10 production in RAW 264.7 macrophages |
Authors: | Nguyen, Manh Khoa Nguyen, Thi Thu Tran, Thi Hien Vu, Thi Diep Ha, Thuy Trang Do, Hong Manh Nguyen, Hoang Tuan Do, Thi Ha |
Keywords: | Cytotoxicity Diterpenoid Interleukin-10 Interleukin-1β Isodon lophanthoides Phenolic acid |
Issue Date: | 2024 |
Series/Report no.: | Vietnam journal of Chemitry;Vol.62, Iss.04 .- P.446-452 |
Abstract: | The bioassay guided isolation of compounds from the aerial parts of Isodon lophanthoides (IL) resulted in the identification of five compounds (1-5). The chemical structures of 1-5 were determined through spectral analyses and compared to those identified in the literature to be 4-hydroxybenzoic acid (1), protocatechuic acid (2), rosmarinic acid (3), coetsoidin B (4), and coetsoidin A (5). Compounds 1, 4, and 5 were found for the first time in the aerial parts of IL. Compounds 1 and 2 displayed potent cytotoxic activity against A549, MCF-7, HepG2, and HL60 cancer cell lines, with IC₅₀ values ranging from 13.93 to 18.69 μμ and from 11.97 to 18.30 µm, respectively. Compounds 1-5 significantly inhibited LPS-induced IL-1β production in RAW 264.7 macrophages compared to the LPS 5 ng/ml control group, resulting in IL-1β concentrations ranging from 34.92 to 46.91 pg/mL. Additionally, compounds 1-5 exhibited notable stimulation of IL- 10 production, with IL-10 levels ranging from 358.77 to 478.23 pg/mL, compared to the LPS 5 ng/mL control group. These findings highlight the potential of compounds 1-5 and the IL extracts for the cytotoxic effects on cancer cell lines and on LPS-induced IL-1β and IL-10 production in RAW 264.7 macrophages. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/109355 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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