Vui lòng dùng định danh này để trích dẫn hoặc liên kết đến tài liệu này: https://dspace.ctu.edu.vn/jspui/handle/123456789/109355
Nhan đề: Compounds from aerial parts of Isodon lophanthoides and their effects of cytotoxicity and LPS-induced IL-1β and IL-10 production in RAW 264.7 macrophages
Tác giả: Nguyen, Manh Khoa
Nguyen, Thi Thu
Tran, Thi Hien
Vu, Thi Diep
Ha, Thuy Trang
Do, Hong Manh
Nguyen, Hoang Tuan
Do, Thi Ha
Từ khoá: Cytotoxicity
Diterpenoid
Interleukin-10
Interleukin-1β
Isodon lophanthoides
Phenolic acid
Năm xuất bản: 2024
Tùng thư/Số báo cáo: Vietnam journal of Chemitry;Vol.62, Iss.04 .- P.446-452
Tóm tắt: The bioassay guided isolation of compounds from the aerial parts of Isodon lophanthoides (IL) resulted in the identification of five compounds (1-5). The chemical structures of 1-5 were determined through spectral analyses and compared to those identified in the literature to be 4-hydroxybenzoic acid (1), protocatechuic acid (2), rosmarinic acid (3), coetsoidin B (4), and coetsoidin A (5). Compounds 1, 4, and 5 were found for the first time in the aerial parts of IL. Compounds 1 and 2 displayed potent cytotoxic activity against A549, MCF-7, HepG2, and HL60 cancer cell lines, with IC₅₀ values ranging from 13.93 to 18.69 μμ and from 11.97 to 18.30 µm, respectively. Compounds 1-5 significantly inhibited LPS-induced IL-1β production in RAW 264.7 macrophages compared to the LPS 5 ng/ml control group, resulting in IL-1β concentrations ranging from 34.92 to 46.91 pg/mL. Additionally, compounds 1-5 exhibited notable stimulation of IL- 10 production, with IL-10 levels ranging from 358.77 to 478.23 pg/mL, compared to the LPS 5 ng/mL control group. These findings highlight the potential of compounds 1-5 and the IL extracts for the cytotoxic effects on cancer cell lines and on LPS-induced IL-1β and IL-10 production in RAW 264.7 macrophages.
Định danh: https://dspace.ctu.edu.vn/jspui/handle/123456789/109355
ISSN: 2525-2321
Bộ sưu tập: Vietnam Journal of Chemistry

Các tập tin trong tài liệu này:
Tập tin Mô tả Kích thước Định dạng  
_file_
  Giới hạn truy cập
2.59 MBAdobe PDF
Your IP: 3.133.145.168


Khi sử dụng các tài liệu trong Thư viện số phải tuân thủ Luật bản quyền.