Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/109440
Title: Terpenes and polyketides from the marinederived fungus Penicillium sp. OPR23-FS02 with cytotoxic and antimicrobial effects
Authors: Do, Hoang Anh
Nguyen, Tien Tu
Tran, Thi Hong Hanh
Nguyen, Xuan Cuong
Le, Thi Vien
Nguyen, Thi Thanh Ngan
Dao, Viet Ha
Tran, Hong Quang
Keywords: Antimicrobial
Cytotoxic
Marine-derived fungus
Penicillium
Polyketide
Terpene
Issue Date: 2024
Series/Report no.: Vietnam journal of Chemitry;Vol.62, Iss.05 .- P.639-646
Abstract: Chemical study of the fermentation culture of the marine-derived fungal strain Penicillium sp. OPR23-FS02 led to isolation of ten secondary metabolites, including two terpenes, purpuride (1) and penioxalicin (2) and eight polyketides, trans-3,4-dihydro-3,4,8-trihydroxynaphthalen-1(2H)-one (3), chloromonilinic acid B (4), chrysophanol (5), emodin (6), w-hydroxyemodin (7), questin (8), endocrocin (9), and ergochrome F (10). Their structures were elucidated by analyzing their NMR and HRESI mass spectra and comparing with the literature data. Compound 9 was weakly cytotoxic against HepG2 cell line, with an IC₅₀ value of 89.86 ± 2.63 μμ. Compounds 4 and 10 showed antimicrobial effect against Enterococcus faecalis whereas 6 inhibited Bacillus cereus growth, with the same MIC values of 64 µm.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/109440
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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