Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/109440
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dc.contributor.authorDo, Hoang Anh-
dc.contributor.authorNguyen, Tien Tu-
dc.contributor.authorTran, Thi Hong Hanh-
dc.contributor.authorNguyen, Xuan Cuong-
dc.contributor.authorLe, Thi Vien-
dc.contributor.authorNguyen, Thi Thanh Ngan-
dc.contributor.authorDao, Viet Ha-
dc.contributor.authorTran, Hong Quang-
dc.date.accessioned2024-12-21T13:53:27Z-
dc.date.available2024-12-21T13:53:27Z-
dc.date.issued2024-
dc.identifier.issn2525-2321-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/109440-
dc.description.abstractChemical study of the fermentation culture of the marine-derived fungal strain Penicillium sp. OPR23-FS02 led to isolation of ten secondary metabolites, including two terpenes, purpuride (1) and penioxalicin (2) and eight polyketides, trans-3,4-dihydro-3,4,8-trihydroxynaphthalen-1(2H)-one (3), chloromonilinic acid B (4), chrysophanol (5), emodin (6), w-hydroxyemodin (7), questin (8), endocrocin (9), and ergochrome F (10). Their structures were elucidated by analyzing their NMR and HRESI mass spectra and comparing with the literature data. Compound 9 was weakly cytotoxic against HepG2 cell line, with an IC₅₀ value of 89.86 ± 2.63 μμ. Compounds 4 and 10 showed antimicrobial effect against Enterococcus faecalis whereas 6 inhibited Bacillus cereus growth, with the same MIC values of 64 µm.vi_VN
dc.language.isoenvi_VN
dc.relation.ispartofseriesVietnam journal of Chemitry;Vol.62, Iss.05 .- P.639-646-
dc.subjectAntimicrobialvi_VN
dc.subjectCytotoxicvi_VN
dc.subjectMarine-derived fungusvi_VN
dc.subjectPenicilliumvi_VN
dc.subjectPolyketidevi_VN
dc.subjectTerpenevi_VN
dc.titleTerpenes and polyketides from the marinederived fungus Penicillium sp. OPR23-FS02 with cytotoxic and antimicrobial effectsvi_VN
dc.typeArticlevi_VN
Appears in Collections:Vietnam Journal of Chemistry

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