Please use this identifier to cite or link to this item:
https://dspace.ctu.edu.vn/jspui/handle/123456789/109634
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bhatt, Keval | - |
dc.contributor.author | Patel, Dhara | - |
dc.contributor.author | Rathod, Mrudangsinh | - |
dc.contributor.author | Patel, Ashish | - |
dc.contributor.author | Shah, Drashti | - |
dc.date.accessioned | 2024-12-24T06:54:32Z | - |
dc.date.available | 2024-12-24T06:54:32Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2525-2321 | - |
dc.identifier.uri | https://dspace.ctu.edu.vn/jspui/handle/123456789/109634 | - |
dc.description.abstract | Imidazo[1,2‐ a]pyridine, a pivotal fused heterocycle with widespread applications in medicinal chemistry, serves as a foundational scaffold for numerous pharmaceutical compounds. This present approach introduces a highly efficient multi‐step synthetic methodology for imidazo[1,2‐ a]pyridine‐8‐carboxamide derivatives through a condensation reaction between 2‐aminonicotinic acid and chloroacetaldehyde in an environmentally friendly ethanol solvent followed by acid‐amine coupling reaction with a substituted amine. This coupling reaction employs an HATU catalyst and DIPEA strong base and affords excellent yields (93%–97%). A total of ten derivatives have been developed and elucidated by spectral methods, including FT‐IR, ¹ H NMR, and mass spectrometry. In summary, this synthetic strategy possesses favorable attributes for the synthesis of imidazo[1,2‐ a]pyridine‐8‐carboxamide derivatives, such as good purity, readily available starting substrates, wide substrate applicability with simple scale‐up and convenient workup procedure. These characteristics render it a promising method for advanced refinement and prospective utilization in synthesizing crucial therapeutic agents. | vi_VN |
dc.language.iso | en | vi_VN |
dc.relation.ispartofseries | Vietnam journal of Chemitry;Vol.62, No.04 .- P.556-565 | - |
dc.subject | Heterocycle | vi_VN |
dc.subject | Imidazo[1,2-a]pyridine | vi_VN |
dc.subject | Multistep synthesis | vi_VN |
dc.title | Efficient synthesis and characterization of imidazo [1,2-a] pyridine-8-carboxamide derivatives: A promising scaffold for drug development | vi_VN |
dc.type | Article | vi_VN |
Appears in Collections: | Vietnam Journal of Chemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
_file_ Restricted Access | 3.08 MB | Adobe PDF | ||
Your IP: 3.145.40.234 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.