Vui lòng dùng định danh này để trích dẫn hoặc liên kết đến tài liệu này:
https://dspace.ctu.edu.vn/jspui/handle/123456789/112261
Toàn bộ biểu ghi siêu dữ liệu
Trường DC | Giá trị | Ngôn ngữ |
---|---|---|
dc.contributor.author | Huynh, Thi Kim Chi | - |
dc.contributor.author | Duong, Bich Ngoc | - |
dc.contributor.author | Ho, Bao Tram | - |
dc.contributor.author | Nguyen, Hoang Phuc | - |
dc.contributor.author | Ton, Anh Khoa | - |
dc.contributor.author | Nguyen, Thi Cam Thu | - |
dc.contributor.author | Nguyen, Thi Hong An | - |
dc.contributor.author | Ngo, Kim Khanh Huy | - |
dc.contributor.author | Phan, Ngoc Kim Ngan | - |
dc.contributor.author | Nguyen, Van Thanh | - |
dc.contributor.author | Hoang, Thi Kim Dung | - |
dc.contributor.author | Le, Quoc Tuan | - |
dc.date.accessioned | 2025-02-28T01:12:44Z | - |
dc.date.available | 2025-02-28T01:12:44Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2525-2321 | - |
dc.identifier.uri | https://dspace.ctu.edu.vn/jspui/handle/123456789/112261 | - |
dc.description.abstract | The Diosmetin Phytosome (Dt-Ph) was developed to enhance the complex's aque ous solubility and in vitro drug release compared to pure Diosmetin (Dt). The process variables such as the reactants' molar ratio, reaction time, stirring speed, and reaction temperature were varied to identify the most appropriate conditions for synthesis. The resulting Dt-Ph possessed a particle size of 213.9 nm, a zeta potential of 115.1 mV, and a 95.6% encapsulation effectiveness, indicating the successful formation of the phytosome. Scanning electron microscopy (SEM) was used to analyze the morphology of the surface of Dt and Dt-Ph. The in vitro disso lution in 24 h and normal cell cytotoxic activities of the selected formulation were evaluated. The solubility of Dt-Ph in buffered media was four times higher than Dt, indicating greater hydrophilicity of Dt-Ph in comparison to the more lipophilic free drug. Additionally, the formulation showed a noticeably increased rate and extent of dissolution studies on drug release, which was two times better than Dt. Cytotoxicity results on HEK-293A cells showed that Dt-Ph had less impact on normal cells compared to Dt. | vi_VN |
dc.language.iso | en | vi_VN |
dc.relation.ispartofseries | Vietnam journal of Chemitry;Vol.62, No.06 .- P.792-803 | - |
dc.subject | Characterization | vi_VN |
dc.subject | Diosmetin | vi_VN |
dc.subject | In vitro drug release | vi_VN |
dc.subject | Lecithin | vi_VN |
dc.subject | Phytosome | vi_VN |
dc.subject | Solubility | vi_VN |
dc.title | Enhanced solubility and in vitro drug release of diosmetin from soy lecithin based - diosmetin phytosome | vi_VN |
dc.type | Article | vi_VN |
Bộ sưu tập: | Vietnam Journal of Chemistry |
Các tập tin trong tài liệu này:
Tập tin | Mô tả | Kích thước | Định dạng | |
---|---|---|---|---|
_file_ Giới hạn truy cập | 4.5 MB | Adobe PDF | ||
Your IP: 216.73.216.129 |
Khi sử dụng các tài liệu trong Thư viện số phải tuân thủ Luật bản quyền.