3D cytotoxic and histon deacetylase (HDAC) inhibitory activities of triterpenoids isolated from leaves of Viburnum sambucinum

Abstract

The plant Viburnum sambucinum has been known under the local name “Vót dạng cơm cháy” belongs to Vibumum genus, a member of the Caprifoliaceae family. Many plants of Viburnum genus are well known for their medicinal properties and are used in the folk medicine for the treatment of various diseases, A variety of structures have been reported from the plants of the genus, such as diterpenes, triterpenes, iridoids, sesquiterpenes, flavonoids, etc. In this study, we describe 3D cytotoxic and histone deacetylase (HDAC) inhibitory activities of two nordammarane triteipenoids hupehenol D (1) and 12 β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanrane (2) isolated from the leaves of Vibumum sambucinum. The result showed that (1) and (2) exhibited a strong activity against 3D models of LLC cell line with the IC₅₀ value of 25.89 µM and 15.58 µM, respectively. Compound 1 weakly inhibited activity of enzyme HDAC with the IC₅₀ of 20.78±2.86 µM while compound 2 exhibited no effect on HDAC at 25 µM.