Secondary metabolites from the marine-derived fungus Paraconiothyrium sp. VK-13

Abstract

Chemical investigation of a fermentation culture of the marine endophytic fungus Paraconiothyrium sp. VK-13 resulted in the isolation of five compounds, including a new phenolic compound, 1-(2,5-dihydroxyphenyl)-1-oxobutan-3-yl acetate (1) and four known metabolites, l-(2,5-dihydroxyphenyl)-2-buten-l-one (2), 3,7-dimethyl-l,8-dihydroxy-6-methoxyisochroman (3), modiolides A (4) and B (5). Their Chemical structures were identified based on 1D, 2D NMR and MS spectroscopic analysis and comparison with the data reported previously in the literature. All the isolated compounds were reported for the first time from the genus Paraconiothyrium.