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https://dspace.ctu.edu.vn/jspui/handle/123456789/22194
Title: | Inhibitory Selaginellins from Selaginella tamariscina against LPS-induced NO production in RAW264.7 cells |
Authors: | Nguyen, Dinh Tuan Do, Thi Thuy Pham, Minh Quan Nguyen, Phi Hung |
Keywords: | Selaginellacae Selaginella tamariscina Selaginellins NO production Inflammation |
Issue Date: | 2019 |
Series/Report no.: | Vietnam Journal of Chemistry;No 57(03) .- Page.324-327 |
Abstract: | Three selaginellins have been isolated and structurally identified as selaginellin (1), selaginellin M (2), and selariscinin B (3) from Selaginella tamariscina, by interpretation of spectroscopic (¹H, ¹³C NMR and MS) data and comparing with literatures. Compounds 1-3 exhibited potential inhibition on lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells with IC₅₀ values of 21.0±1.2, 4.5 ± 0.6, and 18.1±0.9 µM, respectively. Celastrol was used as positive control showing an IC₅₀ value of 1.0±0.1 µM. This obtained data reveals the potential of these selaginellin type compounds in the development of anti-inflammatory agents from medicinal plants. |
URI: | http://dspace.ctu.edu.vn/jspui/handle/123456789/22194 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
Files in This Item:
File | Description | Size | Format | |
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_file_ Restricted Access | 1.9 MB | Adobe PDF | ||
Your IP: 13.59.5.179 |
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