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https://dspace.ctu.edu.vn/jspui/handle/123456789/22196
Title: | Withanolides from the whole plant of Physalis angulata and their anti-inflammatory activities |
Authors: | Pham, Hai Yen Le, Canh Viet Cuong Ton, That Huu Dat Dinh, Thi Quy Thuy Dang, Thi Ngoc Hoa Nguyen, Thi Cuc Duong, Thi Hai Yen Do, Thi Thao Hoang, Le Tuan Anh |
Keywords: | Physalis angulata Anti-inflammatory activity Physagulin L Physagulin M Withaminimin |
Issue Date: | 2019 |
Series/Report no.: | Vietnam Journal of Chemistry;No 57(03) .- Page.334-338 |
Abstract: | From the dichloromethane extract of the whole plant of P. angulata growing in Vietnam, three withanoIides including physagulin L (1), physagulin M (2), and withaminimin (3) were isolated by using various chromatography methods. Their chemical structures were determined by detailed analysis of 1D and 2D-NMR data and comparison with reported data. All isolated compounds were tested for their inhibitory activities against NO production in LPS-stimulated RAW 264.7 macrophages. The results showed that compound 3 had a weak anti-inflammatory activity against NO production in RAW 264.7 macrophages with IC₅₀ value of 69.6±4.5 µM. |
URI: | http://dspace.ctu.edu.vn/jspui/handle/123456789/22196 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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