Synthesis of Valsartan as drug for the treatment of hypertension

Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/22198

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DC Field	Value	Language
dc.contributor.author	Tran, Van Chien	-
dc.contributor.author	Nguyen, The Anh	-
dc.contributor.author	Tran, Thi Phuong Thao	-
dc.contributor.author	Le, Dac Phuong	-
dc.contributor.author	Pham, Thi Tham	-
dc.contributor.author	Nguyen, Quang Tung	-
dc.contributor.author	Tran, Van Loc	-
dc.date.accessioned	2020-03-06T07:31:24Z	-
dc.date.available	2020-03-06T07:31:24Z	-
dc.date.issued	2019	-
dc.identifier.issn	2525-2321	-
dc.identifier.uri	http://dspace.ctu.edu.vn/jspui/handle/123456789/22198	-
dc.description.abstract	The synthesis of valsartan (1), one of the most currently used pharmaceutical agent in antihypertensive therapy, was described through five steps in an overall yield of 54 % starting from 4’-methyl-2-cyanobiphenyl (2). The key step involved tetrazole ring formation catalyzed by Lewis acid. The structures of synthesized compounds were confirmed by means of NMR and MS spectroscopie.	vi_VN
dc.language.iso	en	vi_VN
dc.relation.ispartofseries	Vietnam Journal of Chemistry;No 57(03) .- Page.343-346	-
dc.subject	Valsartan	vi_VN
dc.subject	Antihypertension	vi_VN
dc.subject	Biphenyltetrazole	vi_VN
dc.subject	Lewis acid	vi_VN
dc.title	Synthesis of Valsartan as drug for the treatment of hypertension	vi_VN
dc.type	Article	vi_VN
Appears in Collections:	Vietnam Journal of Chemistry

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