Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/25353
Title: Anti-inflammatory phenylpropanoid glycosides from the roots of Polygala aureocauda Dunn
Authors: Tran, Hong Quang
Duong, Thi Hai Yen
Duong, Thi Dung
Do, Thi Trang
Nguyen, Thi Thanh Ngan
Phan, Van Kiem
Chau, Van Minh
Keywords: Polygala aureocauda
Polygalaceae
Phenylpropanoid glycoside
Anti-intlammatory
Issue Date: 2019
Series/Report no.: Vietnam Journal of Chemistry;Số 57(05) .- Tr.525-530
Abstract: Chemical study on a methanol extract of the roots of Polygala aureocauda Dunn. Resulted in the isolation of three phenylpropanoid glycosides, including β-D-[3-0-(3,4,5-trimethoxycinnamoyl)]-fructofuranosyl-α-D-[6-0-(4-methoxybcnzoyl)]-glucopyranoside (1). β-D-(3-O-sinapoyl)-fructofuranosyl-α-D-(6-O-sinapoyl)-glucopyranoside (2), and tenuifoliside C (3). Their chemical structures were elucidated by NMR and MS spectroscopic analysis in comparison with the data reported in the literature. Of the isolates, compound 1 inhibited NO and PGE₂ overproduction in LPS-stimulated RANV264.7 macrophages, with IC₅₀ value of 29.7 and 28.7 µM. These effects of 1 were shown to be related to its suppressive effects on iNOS and COX-2 protein expression.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/25353
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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