The Pivotal Role of N-0 bonds in the Synthesis of Natural Products: A mini-review

Abstract

This review focuses on the role of the nitrogen-oxygen bond as a structural comer stone for the construction of complex natural Products. This bond may play several roles such as a functional protecting group or an activating group in carbonyl chemistry. Compounds containing a N-0 bond are generally prepared by cycloaddition of nitroso derivatives, nitrones or nitriles oxides. The first two reactions have been used in the synthesis of a N-0 bond containing natural product, pyrinodemin A, or for the synthesis of hydroxylated piperidine alkaloids after N-0 bond cleavage.