Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/27209
Title: Cytotoxic xanthonoids from the stem bark of garcinia hanburyi collected in Vietnam
Authors: Nguyen, Thi Kim An
Ngo, Dai Quang
Pham, Quoc Long
Tran, Thi Thu Thuy
Keywords: Prenylated caged xanthones
Garcinia hanburyi
Gambogic acid
Cytotoxicity
LLC and SK-LU-1
Issue Date: 2020
Series/Report no.: Vietnam Journal of Science and Technology;Vol.58(02) .- P.133-142
Abstract: Five prenylated caged xanthones: desoxymorellin (1), morellic acid (2), gambogic acid (3), isogambogic acid (4) and 10α-butoxy gambogic acid (5), were isolated from the stem bark of Garcinia hanburyi collected in Vietnam. Their structures were elucidated by detailed 1D, 2D NMR, MS spectroscopic analyses and compared with reported data. Two major constituents, gambogic acid and isogambogic acid, displayed strong cytotoxicity against LLC and SK-LU-1cell lines with IC50 values in the range from 0.35±0.05 µM to 2.26±0.19 µM. This is the first study on the cytotoxicity of gambogic acid and isogambogic acid against LLC and SK-LU-1 lung cancer cell lines.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/27209
ISSN: 2525-2518
Appears in Collections:Vietnam journal of science and technology

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