Cytotoxic xanthonoids from the stem bark of garcinia hanburyi collected in Vietnam

Abstract

Five prenylated caged xanthones: desoxymorellin (1), morellic acid (2), gambogic acid (3), isogambogic acid (4) and 10α-butoxy gambogic acid (5), were isolated from the stem bark of Garcinia hanburyi collected in Vietnam. Their structures were elucidated by detailed 1D, 2D NMR, MS spectroscopic analyses and compared with reported data. Two major constituents, gambogic acid and isogambogic acid, displayed strong cytotoxicity against LLC and SK-LU-1cell lines with IC50 values in the range from 0.35±0.05 µM to 2.26±0.19 µM. This is the first study on the cytotoxicity of gambogic acid and isogambogic acid against LLC and SK-LU-1 lung cancer cell lines.