Analyzing I6S rRNA sequences from vietnamese pathogenic leptospira strains and in-silico prediction of potential antigenic epitopes on lipl21, lipl32 outer membrane lipoproteins

Abstract

Leptospirosis, a zoonosis caused by Leptospira, is recognized as an emergent infectious disease. In currently, the lack of adequate diagnostic tools, vaccines are an attractive intervention strategy. In this experiment, a 550 bp fragment of large ribosomal RNA gene (16S rRNA) was sequenced and constructed phylogenetic tree from a panel of six Vietnamese pathogenic strains of Leptospira spirochetes (e.g., Pomona, Canicola, Mitis, letero haemohagiae, Bataviae, and Grippotyphosa).