Activation of CYP1A1, CYP1B1 and AHRR gene in dioxin-exposed people from Da Nang dioxin hotspot

Abstract

Activation of aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other polychlorinated cyclic dioxin congeners was shown to influence many physiological processes including cell cycle, cell migralion, tumorigenic progress and immune function. This canonical pathway involves the modulation of multiple targets, of which group 1 of the cytochrome P450 family (CYP1A1. CYP1A2 and CYP1B1) play central roles in metabolism of drugs, steroids, fatty acids, polycyclic xenobiotic and endogenous compounds. Although this pathway was well demonstrated in a number of studies using cell culture and animal models, very few publications described it in human.