Regulation of inflammatory response by A20 through stat-1 signalling in dendritic cells

Abstract

A20 is negative regulator of NF-KB-mediated activation and inflammation in many cell types including dendritic cells (DCs), key players in the regulation of innate and adaptive immunity. Exposure of DCs to a TLR4 ligand lipopolysaccharide (EPS) induces DC activation and maturation, which is characterised by relcase of inflammatory cytokines, up-regulation of co-stimulatory molecules and induction of migration to the nearest lymph node where they prime the activation and proliferation of naive T cells.