Effect of fluoxetine on the inhibition of adenylate cyclase activity in foskolin-stimulated mltc-1 leydig cells

Abstract

Fluoxetine (FLX), a widely used antidepressant primarily acting as a selective serotonin reuptake inhibitor, has bccn shown to exhibit other mechanisms oi' action in various cell types. Cyclic adenosine monophosphate (cAMP) is a second messenger used for intracellular signal induction. Cyclic AMP is a nucleotide synthesized within the cell from adenosine triphosphate by the adenylyl cyclase enzyme, and is inactivated enzymatically to 5'AMP by hydroxylation with a group of enzymes called phosphodiesterase.