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Title: | Phytochemical screening and cytotoxic evaluation from leaf extracts of combretum quadrangulare and clerodendrum inerme on MCF-7 and HEPG2 cancer cell lines |
Authors: | Ly, Hai Trieu Le, Vu Khanh Trang Le, Van Minh |
Keywords: | Combretum quadrangulare Clerodendrum inerme Phytochemical screening Cytotoxicity MCF-7 HepG2 |
Issue Date: | 2019 |
Series/Report no.: | Journal of Science the University of DaNang- University of Science and Education;Vol. 36 No. 05 .- P.26-32 |
Abstract: | Cancer is the second most common disease causing human deaths worldwide. Recent studies have disclosed that medicinal plants exhibit anti cancer activity through various mechanisms. The present study is aimed at determining cytotoxicities from the leaf extracts of C. quadrangulare and C. inerme, and investigating their extracted secondary metabolites. Phytochemical screening confirmed the presence of phyto-constituents such as phenols, flavonoids, tannins, triterpenoids, saponins, and steroids in C. quadrangulare leaves whereas alkaloids, phenols, flavonoids, tannins, coumarins, triterpenoids, saponins, and steroids were found in C. inerme leaves. The results indicated a different level of cytotoxic activity against MCF-7 and HepG2 cancer cell lines using C. quadrangulare and C. inerme crude or fractionated extracts. Ethyl acetate extraction in both medicinal materials demonstrated higher cytotoxicity. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/32715 |
ISSN: | 1859-4603 |
Appears in Collections: | Khoa học Trường ĐH Sư phạm - Đại học Đà Nẵng |
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