LRC Digital repo
DSpace preserves and enables easy and open access to all types of digital content including text, images, moving images, mpegs and data sets
Please use this identifier to cite or link to this item:
https://dspace.ctu.edu.vn/jspui/handle/123456789/38088| Title: | Synthensis and cytotoxicity of polyhydroxylated cholesterol derivatives |
| Authors: | Dinh, Thi Ha Doan, Lan Phuong Pham, Quoc Long Ngo, Dai Quang Tran, Thi Thu Thuy |
| Keywords: | Cholesterol Cytotoxicity Polyhydroxylated derivative |
| Issue Date: | 2018 |
| Series/Report no.: | Vietnam Journal of Science and Technology;Vol.56(No.04) .- P.467–473 |
| Abstract: | Eight polyhydroxylated cholesterol derivatives (l-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibit human hepatocellular carcinoma cell line (Hep-G2) with IC50 values of 11.59, 11.89 and 6.87 µM' respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50: 2.28 µM. |
| URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/38088 |
| ISSN: | 2525-2518 |
| Appears in Collections: | Vietnam journal of science and technology |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 4.4 MB | Adobe PDF | ||
| Your IP: 3.144.6.236 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.