Please use this identifier to cite or link to this item:
https://dspace.ctu.edu.vn/jspui/handle/123456789/38132
Title: | A systematic study towards evolutionary and epidemiological dynamics of currently predominant H5 highly pathogenic avian infuenza viruses in Vietnam |
Authors: | Nguyen, Thanh Lam Firestone, Simon M. Stevenson, Mark A. Young, Neil D. Sims, Leslie D. Chu, Duc Huy Nguyen, Tien Ngoc Nguyen, Long Van Le, Thanh Tung Nguyen, Van Hung Nguyen, Nam Hung Tien, Ngoc Tien Nguyen, Tho Dang Tran, Bich Ngoc Matsuno, Keita Okamatsu, Masatoshi Kida, Hiroshi Sakoda, Yoshihiro |
Keywords: | Vietnamese H5 HPAIVs |
Issue Date: | 2019 |
Series/Report no.: | Scientific Reports;No. 09 .- P.1-13 |
Abstract: | This study aimed to elucidate virus, host and environmental dynamics of Vietnamese H5 highly pathogenic avian influenza viruses (HPAIVs) during 2014–2017. Epidemiologically, H5 HPAIVs were frequently detected in apparently healthy domestic and Muscovy ducks and therefore these are preferred species for H5 HPAIV detection in active surveillance. Virologically, clade 2.3.2.1c and 2.3.4.4 H5 HPAIVs were predominant and exhibited distinct phylogeographic evolution. Clade 2.3.2.1c viruses clustered phylogenetically in North, Central and South regions, whilst clade 2.3.4.4 viruses only detected in North and Central regions formed small groups. These viruses underwent diverse reassortment with existence of at least 12 genotypes and retained typical avian-specific motifs. These H5 HPAIVs exhibited large antigenic distance from progenitor viruses and commercial vaccines currently used in poultry. Bayesian phylodynamic analysis inferred that clade 2.3.2.1c viruses detected during 2014–2017 were likely descended from homologous clade viruses imported to Vietnam previously and/or preexisting Chinese viruses during 2012–2013. Vietnamese clade 2.3.4.4 viruses closely shared genetic traits with contemporary foreign spillovers, suggesting that there existed multiple transboundary virus dispersals to Vietnam. This study provides insights into the evolution of Vietnamese H5 HPAIVs and highlights the necessity of strengthening control measures such as, preventive surveillance and poultry vaccination. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/38132 |
Appears in Collections: | Tạp chí quốc tế |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
_file_ | 2.73 MB | Adobe PDF | View/Open | |
Your IP: 52.14.176.111 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.