Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/39564
Title: Functions of the WNT Signaling Network in Shaping Host Responses to Infection
Authors: Ljungberg, Johanna K
Kling, Jessica C
Tran, Thao Thanh
Blumenthal, Antje
Keywords: WNT signaling
Anti-microbial defense
Antigen presenting cells (APCS)
Infection
Inflammation
Issue Date: 2019
Series/Report no.: Journal of the International Union of Immunological Societies (IUIS);No. 08 .- P.1-23
Abstract: It is well-established that aberrant WNT expression and signaling is associated with developmental defects, malignant transformation and carcinogenesis. More recently, WNT ligands have emerged as integral components of host responses to infection but their functions in the context of immune responses are incompletely understood. Roles in the modulation of inflammatory cytokine production, host cell intrinsic innate defense mechanisms, as well as the bridging of innate and adaptive immunity have been described. To what degree WNT responses are defined by the nature of the invading pathogen or are specific for subsets of host cells is currently not well-understood. Here we provide an overview of WNT responses during infection with phylogenetically diverse pathogens and highlight functions of WNT ligands in the host defense against infection. Detailed understanding of how the WNT network orchestrates immune cell functions will not only improve our understanding of the fundamental principles underlying complex immune response, but also help identify therapeutic opportunities or potential risks associated with the pharmacological targeting of the WNT network, as currently pursued for novel therapeutics in cancer and bone disorders.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/39564
Appears in Collections:Tạp chí quốc tế

Files in This Item:
File Description SizeFormat 
_file_1.46 MBAdobe PDFView/Open
Your IP: 18.218.50.170


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.