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https://dspace.ctu.edu.vn/jspui/handle/123456789/40858
Title: | The effective pH-responsive 3-aminopropyltriethoxysilane linked with porous nanosilica for doxorubicine delivery |
Authors: | Vo, Uyen Vy Nguyen, Thi Thanh Van Nguyen, Thuy Thuy Linh Phan, Thi Kim Phuong Phan Tran, Thi Thanh Nha Pham, Hoang Ai Lem Nguyen, Anh Khoa Nguyen, Dai Hai Nguyen, Cuu Khoa |
Keywords: | Porous nanosilicas 3-aminopropyltriethoxysilane Doxorubicin Smart drug delivery systems pH-responsive |
Issue Date: | 2018 |
Series/Report no.: | Vietnam Journal of Chemistry;Vol. 56, No. 05 .- P.623-626 |
Abstract: | Porous nanosilica has been identified as an outstanding candidate for controlled drug delivery. However, unmodified PNS-based carriers usually exhibited an initial release of loaded bioactive agents, which may limit their potential clinical applications. In this study, the surface of porous nanosilica was bonded with 3-aminopropyltriethoxysilane for Doxorubicin delivery. The modified PNS was successfully formed with spherical shape and diameter around 70 nm determined by Transmission Electron Microscopy. Drug loading and release behaviors of Doxorubicin/ Porous nanosilica-3-aminopropyltriethoxysilane, in particular, were also tested. This study is expected to improve the stability of PNS for drug delivery system in cancer therapy. |
URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/40858 |
ISSN: | 2525-2321 |
Appears in Collections: | Vietnam Journal of Chemistry |
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File | Description | Size | Format | |
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_file_ Restricted Access | 1.38 MB | Adobe PDF | ||
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