Volatile compounds and biological activities of essential oil of Globba pendula rhizomes collected at An Giang province

Abstract

The present paper describes chemical composition, NO inhibitory activity against lipopolysaccharide (LPS)-induced nitric oxide release, cytotoxic activity against MCF7 and Hep3B cell lines of the essential oil of Globba pendula Roxb. rhizomes. A total of 25 components of the essential oil were identified by using gas chromatography–mass spectrometry (GC-MS), accounting for 89.55 % of the total oil. δ-selinen (36.45 %) and ishwarane (10.76 %) were the main components. The essential oil was found to possess moderate NO inhibitory effect with IC₅₀ of 41.68 ± 4.51 µg/ml, and significant cytotoxic activity against MCF7 and Hep3B cell lines with IC₅₀ of 28.15 ± 1.08 and 35.24 ± 0.06 µg/ml, respectively. This is the first report on volatile compounds and biological activities of the essential oil of Globba pendula Roxb.rhizomes collected in An Giang province, Viet Nam.