The anti cancer activities of stichoposide d isolated from the sea cucumber stichopus chloronotus on ntera-2 cancer stem cells

Abstract

As reported, cancer stem cells (CSCs) are in charge of dangerous characteristics including drug resistance, metastasis, recurrence and therapeutic effectiveness. Therefore, CSCs are an important target for discovering of novel effective and specific anticancer drugs. In Vietnam, the Stichopus chloronotus sca cucumber is found as a potential biological source with various active ingredients. Particularly, the active triterpene saponin stichoposide D. which was isolated from S. chloronotus, showed strong cytotoxic activity in leukemias. Herein, stichoposide D was further studied its potential anti-CSCs activities on pluripotent human embryonic carcinomas NTERA-2 cells.