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https://dspace.ctu.edu.vn/jspui/handle/123456789/44919| Title: | PTP1B inhibitors from Isodon ternifolius collecteted in VietNam |
| Authors: | Pham, Minh Quan Le, Thi Thuy Huong Do, Thi Thuy To, Dao Cuong Pham, Quoc Long Nguyen, Phi Hung |
| Keywords: | Isodon ternifolius Lamiaceae Whole plant Ursane-type triterpene PTP1B |
| Issue Date: | 2020 |
| Series/Report no.: | Vietnam Journal of Science and Technology;Vol. 58, No. 05 .- P.533-540 |
| Abstract: | From the whole plant of Isodon ternifolius collected in Viet Nam, four triterpenes including ursaldehyde (1), ursolic acid (2), β-sitosterol (3), and β-sitosteryl ferulate (4) were isolated. Their chemical structures were determined using NMR and MS spectroscopy methods in combination with literature comparison. Inhibitory activity against PTP1B enzyme activity of isolated compounds also evaluated using in vitro assay. Compounds 1 and 2 displayed potential activities with IC50 values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. For the first time, compounds 1 and 4 were isolated from the Isodon genus and I. ternifolius, as well as evaluated for the PTP1B inhibitory activity. |
| URI: | https://dspace.ctu.edu.vn/jspui/handle/123456789/44919 |
| ISSN: | 2525-2518 |
| Appears in Collections: | Vietnam journal of science and technology |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| _file_ Restricted Access | 4.03 MB | Adobe PDF | ||
| Your IP: 18.116.37.200 |
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