Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/4496
Title: PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation
Authors: Yang, Jun Li
Hà, Thị Kim Quy
Oh, Won Keun
Lee, Ba Wool
Kim, Jinwoong
Keywords: Iris sanguinea
Triterpene
PTP1B
AMPK
Glucose uptake
Issue Date: 2017
Series/Report no.: Bioorganic & Medicinal Chemistry Letters;27 .- p. 5076-5081
Abstract: To find PTP1B inhibitors from natural products, two new compounds (1 and 2), along with nine known compounds (3–11), were isolated from a methanol-soluble extract of Iris sanguinea seeds. The structures of compounds 1 and 2 were determined based on extensive spectroscopic data analysis including UV, IR, NMR, and MS. The IC₅₀ value of compound 5 on protein tyrosine phosphatase 1B (PTP1B) inhibitory activity is 7.30 ± 0.88 mM with a little activity compared to the IC50 values of the tested positive compound. Compound 5 significantly enhanced glucose uptake and activation of pACC, pAMPK and partially Erk1/2 signaling. These results suggest that compound 5 from Iris sanguinea seeds are utilized as both PTP1B inhibitors and regulators of glucose uptake. These beneficial effects could be applied to treat metabolic diseases such as diabetes and obesity.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/4496
Appears in Collections:Tạp chí quốc tế

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