Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/4614
Title: Antiviral phenolics from the leaves of Cleistocalyx operculatus
Authors: Hà, Thị Kim Quy
Kim, Eunhee
Oh, Won Keun
Cho, Tae Oh
Kim, Jiwon
Dao, Trong Tuan
Keywords: H1N1
Influenza neuraminidase
Cleistocalyx operculatus
Myrtaceae
Issue Date: 2016
Series/Report no.: Fitoterapia;110 .- p.135–141
Abstract: During the screening program for anti-influenza agents from medicinal plants, the ethanolic extract of Cleistocalyx operculatus leaves was found to exhibit potential neuraminidase (NA) inhibitory activity. Bioassaydirected fractionation led to the isolation of two new acetophenones (1 and 2) and one new flavanone (3), along with six known compounds (4–9). The structures of all isolated compounds were elucidated using various spectroscopic methods and through comparison with the previous literature. Compounds 6 and 8 exhibited strong enzymatic inhibition on various neuraminidases from different influenza viruses, including H1N1, H9N2, novel H1N1, and oseltamivir-resistant novel H1N1 (H274Y mutation) expressed in HEK293 cells (IC50 values ranging from 5.07 ± 0.94 μM to 9.34 ± 2.52 μM, respectively). Kinetic experiments revealed the non-competitive inhibitory mode of both compounds 6 and 8. Furthermore, these flavonoids reduced the cytopathic effect of the H1N1 virus in MDCK cells. The present study suggests the potential of two flavonoids (6 and 8) as new lead compounds for the development of novel NA inhibitors in the future.
URI: http://dspace.ctu.edu.vn/jspui/handle/123456789/4614
Appears in Collections:Tạp chí quốc tế

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