Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/46167
Title: Five phenolic compounds from Marchantia polymorpha L. and their in vitro antibacterial, antioxidant and cytotoxic activities
Authors: Nguyen, Cong Thai Son
Tran, Quoc Tan
Do, Thi My Lien
Nguyen, Thi My Huong
Pham, Nguyen Kim Tuyen
Nguyen, Kim Phi Phung
Quach, Ngo Diem Phuong
Nguyen, Thi Hoai Thu
Keywords: Marchantia polymorpha
Phenolic
Antibacterial
Antioxidant
Cytotoxicity
Issue Date: 2020
Series/Report no.: Vietnam Journal of Chemistry;No.06, Vol.58 .- P.810-814
Abstract: Lunularin (1), marchantin A (2), isoriccardin C (3), luteolin (4) and apigenin (5) were isolated from the ethyl acetate extract of Marchantia polymorpha collected at Lam Dong province, Vietnam. The chemical structures of these compounds were elucidated by HR-MS and NMR spectroscopic analysis as well as compared with data in the literature. The evaluation of the cytotoxic activity against MCF-7, Hep G2, NCI-H460, and HeLa cancer cell lines of the ethyl acetate extract and compounds (1) and (3) showed that (1) was potent against MCF-7 cancer cell with the IC₅₀ value of 4.59±0.38 µg/mL. The evaluation of DPPH radical scavenging activity displayed strong activities of the ethyl acetate extract, compounds (1) and (3) with SC₅₀ of 12.75±13.27, 3.99±0.47 and 12.81±0.43 µg/mL, respectively, while SC₅₀ of the positive control Trolox was 7.34±0.87 µg/inL. The antibactcrial evaluation on the ethyl acetate extract and two compounds (2) and (3) against staphylococcus epidermidis showed that (3) possessed remarkably antibacterial activity with the inhibition zone of 12.67 mm at a concentration of 50 µg/well.
URI: https://dspace.ctu.edu.vn/jspui/handle/123456789/46167
ISSN: 2525-2321
Appears in Collections:Vietnam Journal of Chemistry

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