Development of Green protocols for the synthesis of 1H-benzo[d]imidazolo aryl amide derivatives and evaluation of their biological activity

Abstract

Benzimidazole scaffold containing Chemical derivatives show superior biological activity. In view of this, we synthesized a combination of benzimidazole and aryl amides. The target compounds (6a-j) were synthesized using ethyl 3-iodobcnzoate and benzimidazole as starting materials under Microwave conditions. The synthesized compounds were screened against gram (+ve) and gram (-ve) bacteria as well as for their anti-oxidant activity. Compound 6a was proved to be most active in inhibiting the DPPH free radical.