Phenolic compounds from Trigonostemon honbaensis and their cytotoxic activity

Abstract

Seven phenolic compounds including (±)-erythro-1-(3',4',5'-trimethoxyphenyl)propane-l,2-diol (1), (±)-threo-1- (3',4',5'-trimethoxyphenyl) propane-l,2-diol (2), (R)-3-3-(3',4'-dimethoxyphenyl) propane-l,2-diol (3), (±)-3-(3',4',5'- trimethoxyphenyl) propane-1,2-diol (4), (+)-syringaresinol (5), (7S,8R,8'R)-5,5'-dimethoxylariciresinol (6), juniperoside (7) were isolated from the leaves of Trigonostemon honbaemis. Their chemical structures were determined using ESI-MS, 1D NMR, and 2D NMR spectra and in comparison with the reported literature. Compounds1- 7 were reported from Trigonoslemongemus for the first time. At concentration of 30 µM, compounds 1-7 exhibited weak cytotoxic activity with cell viability percentages as low as 73.3±0.87 % and 79.5±0.23 % on CAL-27 and MDA-MB231 cell lines, respectively.