Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/4996
Title: Chemical constituents from Melicope pteleifolia leaves
Authors: Nguyen, Ngoc Hieu
Hà, Thị Kim Quy
Vu, Tien Chinh
Tran, The Bach
Lee, Chul Ho
Eum, Sangmi
Choi, Sangho
Oh, Won Keun
Keywords: Melicope pteleifolia
Rutaceae
Spiroketal
Neuraminidase
H1N1
Issue Date: 2016
Series/Report no.: Phytochemistry;130 .- p.291–300
Abstract: Five acetophenones bearing spiroketal-hexofuranoside rings, one di-C-glycosidic acetophenone and two benzopyrans, along with 16 known compounds were isolated from the leaves of Melicope pteleifolia. Structures of all the isolates were elucidated using extensive spectroscopic methods, including 1D, 2DNMR and HRESIMS. All the isolates were also evaluated for their neuraminidase inhibitory activities against H1N1, H9N2, wild-type H1N1 and oseltamivir-resistant H1N1 (H274Y mutation) virus strains. Of the isolates, tamarixetin 3-robinobioside was found to exhibit the strongest enzymatic inhibition (IC50 24.93 ± 3.46, 23.19 ± 5.41, 26.67 ± 5.16 and 40.16 ± 4.50 µM, respectively). Selected candidates, kaempferol 3-robinobioside, kaempferol 3-O-β-D-glucopyranosyl (1/2)-α-D-xylopyranoside and tamarixetin 3-robinobioside, also showed moderate reductions in H1N1-induced cytopathic effects on MDCK cells.
URI: http://localhost:8080//jspui/handle/123456789/4996
Appears in Collections:Tạp chí quốc tế

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