Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/5048
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBùi, Thị Bửu Huê-
dc.contributor.authorHà, Thị Kim Quy-
dc.contributor.authorMai, Văn Hiếu-
dc.contributor.authorTran, Thi Loan-
dc.contributor.authorTran, Phuong Thao-
dc.contributor.authorPham, Canh Em-
dc.contributor.authorTu, Thi Kim Cuc-
dc.contributor.authorNguyen, Tram Yen Chau-
dc.contributor.authorVo, Duc Duy-
dc.contributor.authorOh, Won Keun-
dc.date.accessioned2018-11-20T06:33:30Z-
dc.date.available2018-11-20T06:33:30Z-
dc.date.issued2016-
dc.identifier.urihttp://localhost:8080//jspui/handle/123456789/5048-
dc.description.abstractTwelve new 2-quinolizinylbenzimidazole and 2-naphthalylbenzimidazole derivatives with various 5- and 6-positioned substituents (aza, H, CH₃, Cl, NO₂, NH₂, OCH₃), have been synthesized in moderate to excellent yields via the condensation of 4-oxo-4H-quinolizinecarbaldehyde or naphthalenecarbaldehyde with substituted o-phenylenediamines, o-nitroaniline, and 2,3-pyridinediamine using sodium metabisulfite or sodium hydrosulfite under microwave irradiation. The new benzimidazole derivatives were screened for their cytotoxic activity against the human breast cancer cell line (MCF-7). The results showed on one hand that 2-(substituted quinolizinyl)-1H-benzimidazoles (12b–f) were less active (3–6 fold) than the positive control Tamoxifen (CC₅₀ = 6.52 μM), and on the other hand, among the 2-(substituted naphthalyl)-1H-benzimidazoles series (13a–f), compounds 6,7,8-trimethoxy-3-(5-chloro-1H-benzo[d]imidazol-2-yl)naphthalen-1-ol (13c) (CC₅₀ = 7.48 μM) and 6,7,8-trimethoxy-3-(5-methoxy-1H-benzo [d] imidazol-2-yl)naphthalen-1-ol (13f) (CC₅₀ = 6.43 μM) were found to be as active as Tamoxifen.vi_VN
dc.language.isoenvi_VN
dc.relation.ispartofseriesTetrahedron Letters;57 .- p.887–891-
dc.subject4-Oxo-4H-quinolizinevi_VN
dc.subjectNaphthalenevi_VN
dc.subjectBenzimidazolevi_VN
dc.subjectStobbe condensationvi_VN
dc.subjectMicrowave assisted organic synthesisvi_VN
dc.subjectHuman breast cancer cell linevi_VN
dc.titleMicrowave assisted synthesis and cytotoxic activity evaluations of new benzimidazole derivativesvi_VN
dc.typeArticlevi_VN
Appears in Collections:Tạp chí quốc tế

Files in This Item:
File Description SizeFormat 
_file_541.97 kBAdobe PDFView/Open
Your IP: 3.144.242.20


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.