Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/5247
Title: Reserpine treatment activates AMP activated protein kinase (AMPK)
Authors: Park, Rackhyun
Hà, Thị Kim Quy
Park, Junsoo
Jang, Minsu
Lee, Kang Il
Oh, Won Keun
Kim, Hyunju
Keywords: Reserpine
AMPK
FOXO3a
PC12
MCF-7
Issue Date: 2017
Series/Report no.: Natural Product Sciences;23 .- p.157-161
Abstract: Reserpine is a well-known medicine for the treatment of hypertension, however the role of reserpine in cell signaling is not fully understood. Here, we report that reserpine treatment induces the phosphorylation of AMP activated protein kinase (AMPK) at threonine 172 (T172) in PC12 cells. Phosphorylation of AMPK T172 is regulated by upstream signaling molecules, and the increase of phospho-T172 indicates that AMPK is activated. When we examined the FOXO3a dependent transcription by using the FHRE-Luc reporter assay, reserpine treatment repressed the FHRE-Luc reporter activity in a dose dependent manner. Finally, we showed that reserpine treatment induced the phosphorylation of AMPK as well as cell death in MCF-7 cells. These results suggest that AMPK is a potential cellular target of reserpine.
URI: http://localhost:8080//jspui/handle/123456789/5247
Appears in Collections:Tạp chí quốc tế

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