Please use this identifier to cite or link to this item: https://dspace.ctu.edu.vn/jspui/handle/123456789/54548
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dc.contributor.authorNguyễn, Đức Tài-
dc.contributor.authorLê, Tuấn Anh-
dc.contributor.authorHuỳnh, Thị Ngọc Phương-
dc.date.accessioned2021-06-08T08:19:53Z-
dc.date.available2021-06-08T08:19:53Z-
dc.date.issued2018-
dc.identifier.issn0866-7861-
dc.identifier.urihttps://dspace.ctu.edu.vn/jspui/handle/123456789/54548-
dc.description.abstractFrom 5-bromosalicylaldehyde and some acetophenone derivatives, 5 chalcones were synthesized. Further; 2-pyrazoHne derivatives were synthesized by condensation of the obtained chalcones with hydrazine derivatives. All the 20 synthesized compounds, including 5 chalcones and 15 2-pyrazoline derivatives, were characterized by NMR and MS and evaluated for the bactericidal activities against E. coli ATCC 25922 and S. aureus ATCC 25923. The derivatives of HP6-HP10 (1 -phenyi-2-pyrazoHne derivatives) had a low value of MIC (4-8 pg/ml) on S. aureus. Structure-activity relationships revealed R2 substituent at 1-position of 2-pyrazoHn moiety to be of essential importance for antibacterial activity (R2 of phenyl is better than R2 of hydrogen or acetyl). Besides, haiogenated R1 of the aromatic ring at 3-position of 2-pyrazotin moiety seemed significantly influential on diminution of MIC value.vi_VN
dc.language.isovivi_VN
dc.relation.ispartofseriesTạp chí Dược học;Số 506 .- Tr.30-35,41-
dc.subject2-Pyrazolinevi_VN
dc.subjectSynthesisvi_VN
dc.subjectAntibacterialvi_VN
dc.titleTổng hợp và thử hoạt tính kháng khuẩn của một số dẫn chất 2-pyrazoIinvi_VN
dc.typeArticlevi_VN
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